South Island Researcher Advances Cancer Diagnosis Technology

A childhood friend’s battle with cancer has inspired groundbreaking research by Dr. Judy Ann Cocadiz, a researcher at the University of Otago in New Zealand. Her innovative work aims to enhance the accuracy of early-stage cancer diagnoses and monitoring, potentially transforming the way this disease is detected.

Dr. Cocadiz has been awarded a three-year, $300,000 post-doctoral fellowship from the Cancer Society as part of its 2025 National Research Grant Round. This funding will support her development of a novel tool designed to improve the detection of circulating tumour DNA (ctDNA)—small DNA fragments shed by cancer cells into the bloodstream. The presence of ctDNA correlates with the progression of cancer, with higher levels indicating more advanced disease.

The researcher is focused on creating a small device that can be inserted into a blood vessel, functioning like a “sieve” to capture ctDNA over a brief period. This approach could enable healthcare professionals to detect cancers at much earlier stages and to monitor for any remaining or recurring cancer post-treatment.

Currently, ctDNA is identified through blood samples, usually requiring 8-10ml of blood. Dr. Cocadiz noted the challenges this presents: “In early-stage cancer, there is not a lot of ctDNA in 10ml of blood. It is like looking for a needle in a haystack.” She emphasized the ethical concerns of drawing larger volumes of blood, particularly for vulnerable populations such as children or elderly patients.

The proposed device would minimize patient discomfort by allowing for the collection of ctDNA without the need for extensive blood draws. “Instead of collecting more blood from the patient, it can just be inserted and allowed to collect ctDNA for a few minutes before being removed again,” Dr. Cocadiz explained.

While her research is still in the proof-of-concept stage, Cocadiz envisions the device operating similarly to an intravenous (IV) line. Although it will take years to bring this technology into clinical practice, she expressed optimism about its potential. “I am really optimistic about where my research is heading,” she said, adding, “I am so grateful for this grant from the Cancer Society, because they are not just helping fund this research, but essentially the early stages of my career as well.”

Dr. Cocadiz’s journey into cancer research began in her early childhood while growing up in the Philippines. At just five years old, she observed that her best friend frequently had large bruises from minor injuries. Concerned, she informed her parents, who subsequently took her friend to the doctor. He was diagnosed with early-stage leukaemia, allowing him to receive treatment promptly. Reconnecting with him earlier this year, Dr. Cocadiz was pleased to find him healthy and thriving.

After completing her PhD in biochemistry in 2022, Dr. Cocadiz chose to pursue a path in cancer research over a medical career. “Everything just kind of fell into place, and I am really glad I ended up in cancer research,” she reflected.

This research not only holds promise for enhancing cancer diagnostics but also underscores the profound impact personal experiences can have on scientific pursuits. As Dr. Cocadiz continues her work, the potential for improved early detection methods could benefit countless patients facing cancer in the future.